Safenac solution for injection should not given for more than 2 days , if necessary , treatment can be continued with safenac tablets or suppositories.Each ampoule is for single use only  the solution should be used immediately after opening , any unused contents should be discarded.

Intramuscular injection:

The doses is generally one 75 mg ampoule daily , given by deep intragluteal injection into the upper outer quadrant , in severe cases the daily dose can be increased to two injections of 75 mg .Separated by an interval of a few hours ( one into each buttock ) .

Alternatively , one ampoule of 75 mg can be combined with other forms of safenac ( tablets, suppositories ) up to total maximum daily dose of 150 mg .

Intravenous infusion :

Safenac solution for injection should not be given as an intravenous bolus injection .

Safenac solution for injection should not be mixed with other injection solutions.

Intravenous infusion should be initiated immediately after preparing the infusion solution . the infusion solution should not be stored.

Safenac solution for injection must be diluted with(100-500 ml ) of saline 0.9 % or glucose 5 % infusion solution buffered with sodium bicarbonate .

Clear solutions should be used only . If crystals or precipitates are observed , the infusion solution should not be used.

For the treatment of moderate to severe post –operative pain , 75 mg should be infused continuously over a period of 30 minutes to 2 hours , if necessary , treatment may be repeated after a few hours, but the dose should not exceed 150 mg within any period of 24 hours .

For the prevention of post-operative pain , a loading dose of 25 mg to 50mg should be infused after surgery over 15 minutes to 1 hour , followed by a continuous infusion of about 5 mg per hour up to maximum daily dose of 150 mg .